3-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

3-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a boronic acid derivative valued for its role in carbon–carbon bond-forming reactions used primarily in the pharmaceutical and medicinal chemistry industries. Key applications include suzuki–miyaura cross-coupling for biaryl and heterobiaryl synthesis and metabolic blocking strategy — fluorine substitution to improve drug half-life.

ChemContract Research is a trusted USA-based supplier of 3-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

ChemContract Research supplies 3-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Yes. ChemContract Research offers custom synthesis services for 3-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

The fluorine atom(s) in 3-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like 3-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine valuable in pharmaceutical development.

3-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is primarily used in Suzuki–Miyaura cross-coupling reactions with aryl or vinyl halides under palladium catalysis. This reaction forms C–C bonds with excellent functional group tolerance and mild conditions. It can also be used in Chan–Lam coupling for C–N and C–O bond formation without transition metal catalysts under aerobic conditions.

Store in a tightly sealed container at room temperature under dry conditions. Protect from prolonged moisture exposure. Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

The CAS Registry Number for 3-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is 458532-88-2. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.