Frequently Asked
Common questions about 3-Cyano-4-hydroxy-benzoic acid methyl ester
What is 3-Cyano-4-hydroxy-benzoic acid methyl ester used for?
3-Cyano-4-hydroxy-benzoic acid methyl ester is a carboxylic acid that participates in diverse condensation and coupling reactions used primarily in the pharmaceutical and polymer industries. Key applications include amide bond formation via edc/hobt or hatu coupling in peptide synthesis and prodrug development to mask carboxylic acids and improve membrane permeability.
Where can I buy 3-Cyano-4-hydroxy-benzoic acid methyl ester in the USA?
ChemContract Research is a trusted USA-based supplier of 3-Cyano-4-hydroxy-benzoic acid methyl ester. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 3-Cyano-4-hydroxy-benzoic acid methyl ester?
ChemContract Research supplies 3-Cyano-4-hydroxy-benzoic acid methyl ester in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 3-Cyano-4-hydroxy-benzoic acid methyl ester in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 3-Cyano-4-hydroxy-benzoic acid methyl ester from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What coupling reagents work best with 3-Cyano-4-hydroxy-benzoic acid methyl ester?
For amide bond formation from the carboxylic acid in 3-Cyano-4-hydroxy-benzoic acid methyl ester, HATU/DIPEA is recommended for peptide coupling (high yield, low epimerization). EDC/HOBt is a cost-effective alternative for non-peptide amides. T3P (propylphosphonic acid anhydride) offers excellent atom economy with easy workup. For ester formation, DCC/DMAP (Steglich conditions) or Mitsunobu conditions are standard.
Can the nitrile group in 3-Cyano-4-hydroxy-benzoic acid methyl ester be converted to other functional groups?
Yes. The nitrile (–C≡N) in 3-Cyano-4-hydroxy-benzoic acid methyl ester can be hydrolyzed to a carboxylic acid (strong acid/base, heat) or to an amide (milder conditions, e.g., H₂O₂/base). It can be reduced to a primary amine (LiAlH₄ or catalytic hydrogenation), converted to a tetrazole via [3+2] cycloaddition with NaN₃, or used in Grignard additions to form ketones after hydrolysis.
How should I store 3-Cyano-4-hydroxy-benzoic acid methyl ester?
Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame. Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of 3-Cyano-4-hydroxy-benzoic acid methyl ester?
The CAS Registry Number for 3-Cyano-4-hydroxy-benzoic acid methyl ester is 156001-68-2. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
