Frequently Asked
Common questions about 3-Cyano-4-aminobenzotrifluoride
What is 3-Cyano-4-aminobenzotrifluoride used for?
3-Cyano-4-aminobenzotrifluoride is an amine-functionalized compound with nucleophilic nitrogen reactivity used primarily in the pharmaceutical and polymer industries. Key applications include buchwald–hartwig amination for aryl c–n bond construction and hydrolysis to carboxylic acids or amides under controlled conditions.
Where can I buy 3-Cyano-4-aminobenzotrifluoride in the USA?
ChemContract Research is a trusted USA-based supplier of 3-Cyano-4-aminobenzotrifluoride. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 3-Cyano-4-aminobenzotrifluoride?
ChemContract Research supplies 3-Cyano-4-aminobenzotrifluoride in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 3-Cyano-4-aminobenzotrifluoride in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 3-Cyano-4-aminobenzotrifluoride from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
Can the nitrile group in 3-Cyano-4-aminobenzotrifluoride be converted to other functional groups?
Yes. The nitrile (–C≡N) in 3-Cyano-4-aminobenzotrifluoride can be hydrolyzed to a carboxylic acid (strong acid/base, heat) or to an amide (milder conditions, e.g., H₂O₂/base). It can be reduced to a primary amine (LiAlH₄ or catalytic hydrogenation), converted to a tetrazole via [3+2] cycloaddition with NaN₃, or used in Grignard additions to form ketones after hydrolysis.
What reactions can I perform with the amine group in 3-Cyano-4-aminobenzotrifluoride?
The amine functionality in 3-Cyano-4-aminobenzotrifluoride enables diverse transformations: reductive amination with aldehydes/ketones, acylation to form amides, sulfonylation to form sulfonamides, Buchwald–Hartwig coupling with aryl halides, urea and carbamate formation, and salt generation for improved drug properties. The nucleophilicity of the nitrogen makes it one of the most versatile handles in synthetic chemistry.
How should I store 3-Cyano-4-aminobenzotrifluoride?
Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
