Frequently Asked
Common questions about 3-Chloro-4-(trifluoromethyl) benzonitrile
What is 3-Chloro-4-(trifluoromethyl) benzonitrile used for?
3-Chloro-4-(trifluoromethyl) benzonitrile is a fluorine-containing building block with enhanced metabolic stability used primarily in the pharmaceutical and diagnostic imaging industries. Key applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and nucleophilic aromatic substitution (snar) for ether and amine formation.
Where can I buy 3-Chloro-4-(trifluoromethyl) benzonitrile in the USA?
ChemContract Research is a trusted USA-based supplier of 3-Chloro-4-(trifluoromethyl) benzonitrile. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 3-Chloro-4-(trifluoromethyl) benzonitrile?
ChemContract Research supplies 3-Chloro-4-(trifluoromethyl) benzonitrile in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 3-Chloro-4-(trifluoromethyl) benzonitrile in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 3-Chloro-4-(trifluoromethyl) benzonitrile from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
Can the nitrile group in 3-Chloro-4-(trifluoromethyl) benzonitrile be converted to other functional groups?
Yes. The nitrile (–C≡N) in 3-Chloro-4-(trifluoromethyl) benzonitrile can be hydrolyzed to a carboxylic acid (strong acid/base, heat) or to an amide (milder conditions, e.g., H₂O₂/base). It can be reduced to a primary amine (LiAlH₄ or catalytic hydrogenation), converted to a tetrazole via [3+2] cycloaddition with NaN₃, or used in Grignard additions to form ketones after hydrolysis.
What coupling reactions can I run with 3-Chloro-4-(trifluoromethyl) benzonitrile?
As a chlorinated compound, 3-Chloro-4-(trifluoromethyl) benzonitrile is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.
How should I store 3-Chloro-4-(trifluoromethyl) benzonitrile?
Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
