CAS 157664-47-6 · Amine · 3 functional traits · cGMP compliant · Ships from USA in 2-3 days
3-(Aminomethyl)-2-bromothiophene 95% (CAS Number: 157664-47-6) is an amine-functionalized compound with nucleophilic nitrogen reactivity featuring a Thiophene ring. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.
Amines are among the most prevalent functional groups in drug molecules — over 80% of small-molecule pharmaceuticals contain at least one amine moiety. Aryl and alkyl bromides occupy a "Goldilocks zone" in cross-coupling — more reactive than chlorides yet more stable than iodides — making them the most commonly used coupling partners in process chemistry. Heterocyclic rings appear in approximately 85% of all biologically active compounds. The nitrogen, oxygen, or sulfur heteroatom modulates electron density, hydrogen bonding, and aqueous solubility.
Primary applications include buchwald–hartwig amination for aryl c–n bond construction and grignard reagent preparation via magnesium insertion into c–br bond. This compound serves researchers and manufacturers across the pharmaceutical, polymer, agrochemical sectors. Whether you require 3-(Aminomethyl)-2-bromothiophene 95% for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.
How 3-(Aminomethyl)-2-bromothiophene 95% is used across pharmaceutical and polymer sectors
Buchwald–Hartwig amination for aryl C–N bond construction
Grignard reagent preparation via magnesium insertion into C–Br bond
Core scaffold in kinase inhibitor design for oncology therapeutics
Reductive amination with aldehydes and ketones for secondary amine synthesis
Palladium-catalyzed Suzuki, Heck, and Negishi cross-coupling
GPCR modulator development for CNS and cardiovascular indications
Detailed specifications for this amine, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:
Amines may have strong odors and can be corrosive to skin. Handle under adequate ventilation with chemical-resistant gloves and eye protection. Some brominated compounds may be lachrymatory or skin irritants. Handle in a fume hood with appropriate PPE. Handle with standard laboratory precautions. Some heterocycles may be hygroscopic or irritating. Use adequate ventilation.
Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at room temperature in a tightly sealed, light-resistant container. Some bromo compounds require refrigeration. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive.
Amines are the most prevalent pharmacophore in drug molecules. 3-(Aminomethyl)-2-bromothiophene 95% is supplied with salt-form options and free-base conversion protocols.
Every batch of 3-(Aminomethyl)-2-bromothiophene 95% is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.
Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.
Need a specific grade, quantity, or derivative of 3-(Aminomethyl)-2-bromothiophene 95%? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.
Common questions about 3-(Aminomethyl)-2-bromothiophene 95%
3-(Aminomethyl)-2-bromothiophene 95% is an amine-functionalized compound with nucleophilic nitrogen reactivity used primarily in the pharmaceutical and polymer industries. Key applications include buchwald–hartwig amination for aryl c–n bond construction and grignard reagent preparation via magnesium insertion into c–br bond.
ChemContract Research is a trusted USA-based supplier of 3-(Aminomethyl)-2-bromothiophene 95%. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
ChemContract Research supplies 3-(Aminomethyl)-2-bromothiophene 95% in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Yes. ChemContract Research offers custom synthesis services for 3-(Aminomethyl)-2-bromothiophene 95% from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
The amine functionality in 3-(Aminomethyl)-2-bromothiophene 95% enables diverse transformations: reductive amination with aldehydes/ketones, acylation to form amides, sulfonylation to form sulfonamides, Buchwald–Hartwig coupling with aryl halides, urea and carbamate formation, and salt generation for improved drug properties. The nucleophilicity of the nitrogen makes it one of the most versatile handles in synthetic chemistry.
As a brominated compound, 3-(Aminomethyl)-2-bromothiophene 95% is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.
Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at room temperature in a tightly sealed, light-resistant container. Some bromo compounds require refrigeration. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
The CAS Registry Number for 3-(Aminomethyl)-2-bromothiophene 95% is 157664-47-6. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
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