Frequently Asked
Common questions about 2,4-Difluoro-6-hydroxybenzoic acid methyl ester
What is 2,4-Difluoro-6-hydroxybenzoic acid methyl ester used for?
2,4-Difluoro-6-hydroxybenzoic acid methyl ester is a fluorine-containing building block with enhanced metabolic stability used primarily in the pharmaceutical and diagnostic imaging industries. Key applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and amide bond formation via edc/hobt or hatu coupling in peptide synthesis.
Where can I buy 2,4-Difluoro-6-hydroxybenzoic acid methyl ester in the USA?
ChemContract Research is a trusted USA-based supplier of 2,4-Difluoro-6-hydroxybenzoic acid methyl ester. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 2,4-Difluoro-6-hydroxybenzoic acid methyl ester?
ChemContract Research supplies 2,4-Difluoro-6-hydroxybenzoic acid methyl ester in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 2,4-Difluoro-6-hydroxybenzoic acid methyl ester in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 2,4-Difluoro-6-hydroxybenzoic acid methyl ester from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
Why is fluorine important in 2,4-Difluoro-6-hydroxybenzoic acid methyl ester?
The fluorine atom(s) in 2,4-Difluoro-6-hydroxybenzoic acid methyl ester confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like 2,4-Difluoro-6-hydroxybenzoic acid methyl ester valuable in pharmaceutical development.
What coupling reagents work best with 2,4-Difluoro-6-hydroxybenzoic acid methyl ester?
For amide bond formation from the carboxylic acid in 2,4-Difluoro-6-hydroxybenzoic acid methyl ester, HATU/DIPEA is recommended for peptide coupling (high yield, low epimerization). EDC/HOBt is a cost-effective alternative for non-peptide amides. T3P (propylphosphonic acid anhydride) offers excellent atom economy with easy workup. For ester formation, DCC/DMAP (Steglich conditions) or Mitsunobu conditions are standard.
How should I store 2,4-Difluoro-6-hydroxybenzoic acid methyl ester?
Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
