CAS 69716-28-5 · Chlorinated Compound · 3 functional traits · cGMP compliant · Ships from USA in 2-3 days
2-Pyridinecarboximidoyl chloride, N-hydroxy- (CAS Number: 69716-28-5) is a chloro-substituted intermediate widely used in nucleophilic displacement reactions featuring a Pyridine ring. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.
Chloro substituents serve a dual role in drug design — as synthetic handles for late-stage functionalization and as bioisosteres that modulate lipophilicity and binding affinity. Heterocyclic rings appear in approximately 85% of all biologically active compounds. The nitrogen, oxygen, or sulfur heteroatom modulates electron density, hydrogen bonding, and aqueous solubility. Hydroxyl groups are critical pharmacophores — they serve as hydrogen-bond donors and acceptors, influencing drug–target binding, aqueous solubility, and metabolic susceptibility.
Primary applications include nucleophilic aromatic substitution (snar) for ether and amine formation and core scaffold in kinase inhibitor design for oncology therapeutics. This compound serves researchers and manufacturers across the pharmaceutical, agrochemical, fine chemical sectors. Whether you require 2-Pyridinecarboximidoyl chloride, N-hydroxy- for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.
How 2-Pyridinecarboximidoyl chloride, N-hydroxy- is used across pharmaceutical and agrochemical sectors
Nucleophilic aromatic substitution (SNAr) for ether and amine formation
Core scaffold in kinase inhibitor design for oncology therapeutics
Mitsunobu reaction substrate for stereospecific inversion at chiral centers
Grignard reagent precursor for C–C bond construction
GPCR modulator development for CNS and cardiovascular indications
Oxidation to aldehydes (Swern, Dess–Martin) or ketones for downstream chemistry
Detailed specifications for this chlorinated compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:
Some chlorinated compounds are volatile or irritating. Use a fume hood and appropriate PPE. Acid chlorides react vigorously with water. Handle with standard laboratory precautions. Some heterocycles may be hygroscopic or irritating. Use adequate ventilation. Handle with standard precautions. Some alcohols are flammable. Use adequate ventilation and appropriate PPE.
Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature in a tightly sealed container away from heat sources and oxidizers.
Every batch of 2-Pyridinecarboximidoyl chloride, N-hydroxy- is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.
Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.
Need a specific grade, quantity, or derivative of 2-Pyridinecarboximidoyl chloride, N-hydroxy-? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.
Common questions about 2-Pyridinecarboximidoyl chloride, N-hydroxy-
2-Pyridinecarboximidoyl chloride, N-hydroxy- is a chloro-substituted intermediate widely used in nucleophilic displacement reactions used primarily in the pharmaceutical and agrochemical industries. Key applications include nucleophilic aromatic substitution (snar) for ether and amine formation and core scaffold in kinase inhibitor design for oncology therapeutics.
ChemContract Research is a trusted USA-based supplier of 2-Pyridinecarboximidoyl chloride, N-hydroxy-. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
ChemContract Research supplies 2-Pyridinecarboximidoyl chloride, N-hydroxy- in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Yes. ChemContract Research offers custom synthesis services for 2-Pyridinecarboximidoyl chloride, N-hydroxy- from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
As a chlorinated compound, 2-Pyridinecarboximidoyl chloride, N-hydroxy- is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.
The Pyridine ring system(s) in 2-Pyridinecarboximidoyl chloride, N-hydroxy- is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.
Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature in a tightly sealed container away from heat sources and oxidizers. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
The CAS Registry Number for 2-Pyridinecarboximidoyl chloride, N-hydroxy- is 69716-28-5. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
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