Frequently Asked
Common questions about 2-Fluoro-3-hydroxybenzonitrile
What is 2-Fluoro-3-hydroxybenzonitrile used for?
2-Fluoro-3-hydroxybenzonitrile is a fluorine-containing building block with enhanced metabolic stability used primarily in the pharmaceutical and diagnostic imaging industries. Key applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and mitsunobu reaction substrate for stereospecific inversion at chiral centers.
Where can I buy 2-Fluoro-3-hydroxybenzonitrile in the USA?
ChemContract Research is a trusted USA-based supplier of 2-Fluoro-3-hydroxybenzonitrile. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 2-Fluoro-3-hydroxybenzonitrile?
ChemContract Research supplies 2-Fluoro-3-hydroxybenzonitrile in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 2-Fluoro-3-hydroxybenzonitrile in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 2-Fluoro-3-hydroxybenzonitrile from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
Can the nitrile group in 2-Fluoro-3-hydroxybenzonitrile be converted to other functional groups?
Yes. The nitrile (–C≡N) in 2-Fluoro-3-hydroxybenzonitrile can be hydrolyzed to a carboxylic acid (strong acid/base, heat) or to an amide (milder conditions, e.g., H₂O₂/base). It can be reduced to a primary amine (LiAlH₄ or catalytic hydrogenation), converted to a tetrazole via [3+2] cycloaddition with NaN₃, or used in Grignard additions to form ketones after hydrolysis.
Why is fluorine important in 2-Fluoro-3-hydroxybenzonitrile?
The fluorine atom(s) in 2-Fluoro-3-hydroxybenzonitrile confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like 2-Fluoro-3-hydroxybenzonitrile valuable in pharmaceutical development.
How should I store 2-Fluoro-3-hydroxybenzonitrile?
Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container away from heat sources and oxidizers. Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
