Frequently Asked
Common questions about 2-Chloro-5-methoxybenzonitrile
What is 2-Chloro-5-methoxybenzonitrile used for?
2-Chloro-5-methoxybenzonitrile is a chloro-substituted intermediate widely used in nucleophilic displacement reactions used primarily in the pharmaceutical and agrochemical industries. Key applications include nucleophilic aromatic substitution (snar) for ether and amine formation and hydrolysis to carboxylic acids or amides under controlled conditions.
Where can I buy 2-Chloro-5-methoxybenzonitrile in the USA?
ChemContract Research is a trusted USA-based supplier of 2-Chloro-5-methoxybenzonitrile. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 2-Chloro-5-methoxybenzonitrile?
ChemContract Research supplies 2-Chloro-5-methoxybenzonitrile in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 2-Chloro-5-methoxybenzonitrile in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 2-Chloro-5-methoxybenzonitrile from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What coupling reactions can I run with 2-Chloro-5-methoxybenzonitrile?
As a chlorinated compound, 2-Chloro-5-methoxybenzonitrile is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.
Can the nitrile group in 2-Chloro-5-methoxybenzonitrile be converted to other functional groups?
Yes. The nitrile (–C≡N) in 2-Chloro-5-methoxybenzonitrile can be hydrolyzed to a carboxylic acid (strong acid/base, heat) or to an amide (milder conditions, e.g., H₂O₂/base). It can be reduced to a primary amine (LiAlH₄ or catalytic hydrogenation), converted to a tetrazole via [3+2] cycloaddition with NaN₃, or used in Grignard additions to form ketones after hydrolysis.
How should I store 2-Chloro-5-methoxybenzonitrile?
Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
