Frequently Asked
Common questions about 2-Bromo-5-chlorobenzoic acid
What is 2-Bromo-5-chlorobenzoic acid used for?
2-Bromo-5-chlorobenzoic acid is a bromo-substituted intermediate prized for its reactivity in metal-catalyzed coupling used primarily in the pharmaceutical and fine chemical industries. Key applications include grignard reagent preparation via magnesium insertion into c–br bond and nucleophilic aromatic substitution (snar) for ether and amine formation.
Where can I buy 2-Bromo-5-chlorobenzoic acid in the USA?
ChemContract Research is a trusted USA-based supplier of 2-Bromo-5-chlorobenzoic acid. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 2-Bromo-5-chlorobenzoic acid?
ChemContract Research supplies 2-Bromo-5-chlorobenzoic acid in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 2-Bromo-5-chlorobenzoic acid in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 2-Bromo-5-chlorobenzoic acid from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What coupling reagents work best with 2-Bromo-5-chlorobenzoic acid?
For amide bond formation from the carboxylic acid in 2-Bromo-5-chlorobenzoic acid, HATU/DIPEA is recommended for peptide coupling (high yield, low epimerization). EDC/HOBt is a cost-effective alternative for non-peptide amides. T3P (propylphosphonic acid anhydride) offers excellent atom economy with easy workup. For ester formation, DCC/DMAP (Steglich conditions) or Mitsunobu conditions are standard.
What coupling reactions can I run with 2-Bromo-5-chlorobenzoic acid?
As a brominated compound, 2-Bromo-5-chlorobenzoic acid is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.
How should I store 2-Bromo-5-chlorobenzoic acid?
Store at room temperature in a tightly sealed, light-resistant container. Some bromo compounds require refrigeration. Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of 2-Bromo-5-chlorobenzoic acid?
The CAS Registry Number for 2-Bromo-5-chlorobenzoic acid is 21739-93-5. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
