Frequently Asked
Common questions about 2-Amino-6-fluoro-3-nitrobenzoic acid ethyl ester
What is 2-Amino-6-fluoro-3-nitrobenzoic acid ethyl ester used for?
2-Amino-6-fluoro-3-nitrobenzoic acid ethyl ester is an amine-functionalized compound with nucleophilic nitrogen reactivity used primarily in the pharmaceutical and polymer industries. Key applications include buchwald–hartwig amination for aryl c–n bond construction and metabolic blocking strategy — fluorine substitution to improve drug half-life.
Where can I buy 2-Amino-6-fluoro-3-nitrobenzoic acid ethyl ester in the USA?
ChemContract Research is a trusted USA-based supplier of 2-Amino-6-fluoro-3-nitrobenzoic acid ethyl ester. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 2-Amino-6-fluoro-3-nitrobenzoic acid ethyl ester?
ChemContract Research supplies 2-Amino-6-fluoro-3-nitrobenzoic acid ethyl ester in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 2-Amino-6-fluoro-3-nitrobenzoic acid ethyl ester in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 2-Amino-6-fluoro-3-nitrobenzoic acid ethyl ester from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What coupling reagents work best with 2-Amino-6-fluoro-3-nitrobenzoic acid ethyl ester?
For amide bond formation from the carboxylic acid in 2-Amino-6-fluoro-3-nitrobenzoic acid ethyl ester, HATU/DIPEA is recommended for peptide coupling (high yield, low epimerization). EDC/HOBt is a cost-effective alternative for non-peptide amides. T3P (propylphosphonic acid anhydride) offers excellent atom economy with easy workup. For ester formation, DCC/DMAP (Steglich conditions) or Mitsunobu conditions are standard.
What reactions can I perform with the amine group in 2-Amino-6-fluoro-3-nitrobenzoic acid ethyl ester?
The amine functionality in 2-Amino-6-fluoro-3-nitrobenzoic acid ethyl ester enables diverse transformations: reductive amination with aldehydes/ketones, acylation to form amides, sulfonylation to form sulfonamides, Buchwald–Hartwig coupling with aryl halides, urea and carbamate formation, and salt generation for improved drug properties. The nucleophilicity of the nitrogen makes it one of the most versatile handles in synthetic chemistry.
How should I store 2-Amino-6-fluoro-3-nitrobenzoic acid ethyl ester?
Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
