Frequently Asked
Common questions about 2-Amino-4-(trifluoromethyl)benzonitrile
What is 2-Amino-4-(trifluoromethyl)benzonitrile used for?
2-Amino-4-(trifluoromethyl)benzonitrile is an amine-functionalized compound with nucleophilic nitrogen reactivity used primarily in the pharmaceutical and polymer industries. Key applications include buchwald–hartwig amination for aryl c–n bond construction and metabolic blocking strategy — fluorine substitution to improve drug half-life.
Where can I buy 2-Amino-4-(trifluoromethyl)benzonitrile in the USA?
ChemContract Research is a trusted USA-based supplier of 2-Amino-4-(trifluoromethyl)benzonitrile. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 2-Amino-4-(trifluoromethyl)benzonitrile?
ChemContract Research supplies 2-Amino-4-(trifluoromethyl)benzonitrile in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 2-Amino-4-(trifluoromethyl)benzonitrile in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 2-Amino-4-(trifluoromethyl)benzonitrile from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
Why is fluorine important in 2-Amino-4-(trifluoromethyl)benzonitrile?
The fluorine atom(s) in 2-Amino-4-(trifluoromethyl)benzonitrile confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like 2-Amino-4-(trifluoromethyl)benzonitrile valuable in pharmaceutical development.
What reactions can I perform with the amine group in 2-Amino-4-(trifluoromethyl)benzonitrile?
The amine functionality in 2-Amino-4-(trifluoromethyl)benzonitrile enables diverse transformations: reductive amination with aldehydes/ketones, acylation to form amides, sulfonylation to form sulfonamides, Buchwald–Hartwig coupling with aryl halides, urea and carbamate formation, and salt generation for improved drug properties. The nucleophilicity of the nitrogen makes it one of the most versatile handles in synthetic chemistry.
How should I store 2-Amino-4-(trifluoromethyl)benzonitrile?
Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of 2-Amino-4-(trifluoromethyl)benzonitrile?
The CAS Registry Number for 2-Amino-4-(trifluoromethyl)benzonitrile is 1483-54-1. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
