Frequently Asked
Common questions about 2-Amino-3-hydroxybenzoic acid
What is 2-Amino-3-hydroxybenzoic acid used for?
2-Amino-3-hydroxybenzoic acid is an amine-functionalized compound with nucleophilic nitrogen reactivity used primarily in the pharmaceutical and polymer industries. Key applications include buchwald–hartwig amination for aryl c–n bond construction and amide bond formation via edc/hobt or hatu coupling in peptide synthesis.
Where can I buy 2-Amino-3-hydroxybenzoic acid in the USA?
ChemContract Research is a trusted USA-based supplier of 2-Amino-3-hydroxybenzoic acid. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 2-Amino-3-hydroxybenzoic acid?
ChemContract Research supplies 2-Amino-3-hydroxybenzoic acid in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 2-Amino-3-hydroxybenzoic acid in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 2-Amino-3-hydroxybenzoic acid from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What reactions can I perform with the amine group in 2-Amino-3-hydroxybenzoic acid?
The amine functionality in 2-Amino-3-hydroxybenzoic acid enables diverse transformations: reductive amination with aldehydes/ketones, acylation to form amides, sulfonylation to form sulfonamides, Buchwald–Hartwig coupling with aryl halides, urea and carbamate formation, and salt generation for improved drug properties. The nucleophilicity of the nitrogen makes it one of the most versatile handles in synthetic chemistry.
What coupling reagents work best with 2-Amino-3-hydroxybenzoic acid?
For amide bond formation from the carboxylic acid in 2-Amino-3-hydroxybenzoic acid, HATU/DIPEA is recommended for peptide coupling (high yield, low epimerization). EDC/HOBt is a cost-effective alternative for non-peptide amides. T3P (propylphosphonic acid anhydride) offers excellent atom economy with easy workup. For ester formation, DCC/DMAP (Steglich conditions) or Mitsunobu conditions are standard.
How should I store 2-Amino-3-hydroxybenzoic acid?
Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of 2-Amino-3-hydroxybenzoic acid?
The CAS Registry Number for 2-Amino-3-hydroxybenzoic acid is 548-93-6. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
