Frequently Asked
Common questions about 1H-Indole-4-acetonitrile
What is 1H-Indole-4-acetonitrile used for?
1H-Indole-4-acetonitrile is a heterocycle-containing compound — the dominant scaffold class in approved pharmaceuticals used primarily in the pharmaceutical and medicinal chemistry industries. Key applications include core scaffold in kinase inhibitor design for oncology therapeutics and hydrolysis to carboxylic acids or amides under controlled conditions.
Where can I buy 1H-Indole-4-acetonitrile in the USA?
ChemContract Research is a trusted USA-based supplier of 1H-Indole-4-acetonitrile. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 1H-Indole-4-acetonitrile?
ChemContract Research supplies 1H-Indole-4-acetonitrile in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 1H-Indole-4-acetonitrile in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 1H-Indole-4-acetonitrile from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
Can the nitrile group in 1H-Indole-4-acetonitrile be converted to other functional groups?
Yes. The nitrile (–C≡N) in 1H-Indole-4-acetonitrile can be hydrolyzed to a carboxylic acid (strong acid/base, heat) or to an amide (milder conditions, e.g., H₂O₂/base). It can be reduced to a primary amine (LiAlH₄ or catalytic hydrogenation), converted to a tetrazole via [3+2] cycloaddition with NaN₃, or used in Grignard additions to form ketones after hydrolysis.
What drug discovery applications use 1H-Indole-4-acetonitrile?
The Indole ring system(s) in 1H-Indole-4-acetonitrile is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.
How should I store 1H-Indole-4-acetonitrile?
Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of 1H-Indole-4-acetonitrile?
The CAS Registry Number for 1H-Indole-4-acetonitrile is 30933-66-5. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
