1H-Indole-3-carboxylic acid, 6-(trifluoromethyl)-, methyl ester

1H-Indole-3-carboxylic acid, 6-(trifluoromethyl)-, methyl ester is a fluorine-containing building block with enhanced metabolic stability used primarily in the pharmaceutical and diagnostic imaging industries. Key applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and core scaffold in kinase inhibitor design for oncology therapeutics.

ChemContract Research is a trusted USA-based supplier of 1H-Indole-3-carboxylic acid, 6-(trifluoromethyl)-, methyl ester. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

ChemContract Research supplies 1H-Indole-3-carboxylic acid, 6-(trifluoromethyl)-, methyl ester in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Yes. ChemContract Research offers custom synthesis services for 1H-Indole-3-carboxylic acid, 6-(trifluoromethyl)-, methyl ester from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

The fluorine atom(s) in 1H-Indole-3-carboxylic acid, 6-(trifluoromethyl)-, methyl ester confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like 1H-Indole-3-carboxylic acid, 6-(trifluoromethyl)-, methyl ester valuable in pharmaceutical development.

The Indole ring system(s) in 1H-Indole-3-carboxylic acid, 6-(trifluoromethyl)-, methyl ester is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.

Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

The CAS Registry Number for 1H-Indole-3-carboxylic acid, 6-(trifluoromethyl)-, methyl ester is 415918-12-6. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.