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1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate

CAS 1566649-47-5 · Fluorinated Compound · 3 functional traits · cGMP compliant · Ships from USA in 2-3 days

Fluorinated Compound

1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate

Fluorinated PharmaceuticalDiagnostic ImagingAgrochemicalMaterials SciencePolymerFine Chemical
CAS Number 1566649-47-5
Category Fluorinated Compound · Ester
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate

1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate (CAS Number: 1566649-47-5) is a fluorine-containing building block with enhanced metabolic stability. ChemContract Research supplies this simple-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States. Supplied as the trifluoroacetate salt form for enhanced stability and handling.

The carbon–fluorine bond is the strongest single bond to carbon (485 kJ/mol). This exceptional stability underpins the "fluorine scan" strategy used in medicinal chemistry to optimize drug candidates. Ester hydrolysis by cellular esterases is the most commonly exploited prodrug activation mechanism — enabling drugs that cannot cross biological membranes as free acids. TFA salts are the default isolation form for amines purified by reversed-phase HPLC or deprotected from Boc groups. Salt exchange to HCl or free base is typically required before biological testing.

Primary applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and prodrug development to mask carboxylic acids and improve membrane permeability. This compound serves researchers and manufacturers across the pharmaceutical, diagnostic imaging, agrochemical sectors. Whether you require 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Functional Groups: Ester (–COOR)Fluorine (C–F)
Salt Form: Trifluoroacetate

Fluorinated Compound Applications & Target Industries

How 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate is used across pharmaceutical and diagnostic imaging sectors

01

Metabolic blocking strategy — fluorine substitution to improve drug half-life

02

Prodrug development to mask carboxylic acids and improve membrane permeability

03

Commonly isolated form from Boc deprotection in peptide synthesis

04

PET radiotracer precursor ([¹⁸F]-labeling) for diagnostic imaging

05

Protecting group for hydroxyl functionalities (acetate, benzoate)

06

TFA salt-to-free-base or HCl salt conversion for formulation development

Target Industries: PharmaceuticalDiagnostic ImagingAgrochemicalMaterials SciencePolymerFine Chemical

1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate Specifications

Detailed specifications for this fluorinated compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate
Type Fluorinated Compound
Category Fluorinated Compound · Ester
Purity ≥95% (custom grades available)
Salt Form Trifluoroacetate
Complexity Simple (2 functional groups, 0 rings)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Fluorinated Compounds

Handling Guidelines

Handle with care in a well-ventilated fume hood. Some fluorinated compounds may release HF upon decomposition. Use chemical-resistant gloves. Some esters are volatile and flammable. Handle in a well-ventilated area. Keep away from ignition sources. TFA salts are hygroscopic. Handle in a dry environment. TFA is corrosive — wear chemical-resistant gloves.

Storage Conditions

Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container away from heat and open flame. Store desiccated at –20 °C or as recommended. Protect from moisture to prevent deliquescence.

Why Buy 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate From ChemContract?

Quality Assured

Every batch of 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate

What is 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate used for? +

1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate is a fluorine-containing building block with enhanced metabolic stability used primarily in the pharmaceutical and diagnostic imaging industries. Key applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and prodrug development to mask carboxylic acids and improve membrane permeability.

Where can I buy 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate in the USA? +

ChemContract Research is a trusted USA-based supplier of 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate? +

ChemContract Research supplies 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

Can I get 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate in a different salt form or as the free base? +

Yes. ChemContract Research can supply 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate as the free base or convert it to alternative salt forms including hydrochloride, mesylate, tosylate, fumarate, or other pharmaceutically acceptable counter-ions. Salt form selection impacts crystallinity, stability, and solubility — our chemistry team can advise on optimal salt selection for your application. Currently supplied as the Trifluoroacetate form.

Why is fluorine important in 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate? +

The fluorine atom(s) in 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate valuable in pharmaceutical development.

How should I store 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate? +

Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container away from heat and open flame. Store desiccated at –20 °C or as recommended. Protect from moisture to prevent deliquescence. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate? +

The CAS Registry Number for 1,7-diazaspiro[4.4]nonan-2-one trifluoroacetate is 1566649-47-5. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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