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1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid

CAS 891190-52-6 · Chlorinated Compound · 4 functional traits · cGMP compliant · Ships from USA in 2-3 days

Chlorinated Compound

1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid

Heterocycles PharmaceuticalAgrochemicalFine ChemicalChemical ManufacturingMedicinal ChemistryCatalysis
CAS Number 891190-52-6
Category Chlorinated Compound · Heterocyclic Compound
Origin USA
Compliance cGMP

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About 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid

1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid (CAS Number: 891190-52-6) is a chloro-substituted intermediate widely used in nucleophilic displacement reactions featuring Pyrimidine, Benzene ring systems with defined stereochemistry. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.

Chloro substituents serve a dual role in drug design — as synthetic handles for late-stage functionalization and as bioisosteres that modulate lipophilicity and binding affinity. Heterocyclic rings appear in approximately 85% of all biologically active compounds. The nitrogen, oxygen, or sulfur heteroatom modulates electron density, hydrogen bonding, and aqueous solubility. Carboxylic acids are among the most synthetically versatile functional groups — they can be converted to amides, esters, acid chlorides, anhydrides, alcohols, and aldehydes in a single step.

Primary applications include nucleophilic aromatic substitution (snar) for ether and amine formation and core scaffold in kinase inhibitor design for oncology therapeutics. This compound serves researchers and manufacturers across the pharmaceutical, agrochemical, fine chemical sectors. Whether you require 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: PyrimidineBenzene
Functional Groups: Carboxylic acid (–COOH)Chlorine (C–Cl)
Stereochemistry: Defined Configuration

Chlorinated Compound Applications & Target Industries

How 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid is used across pharmaceutical and agrochemical sectors

01

Nucleophilic aromatic substitution (SNAr) for ether and amine formation

02

Core scaffold in kinase inhibitor design for oncology therapeutics

03

Amide bond formation via EDC/HOBt or HATU coupling in peptide synthesis

04

Enantiopure building block for single-enantiomer drug development

05

Grignard reagent precursor for C–C bond construction

06

GPCR modulator development for CNS and cardiovascular indications

Target Industries: PharmaceuticalAgrochemicalFine ChemicalChemical ManufacturingMedicinal ChemistryCatalysis

1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid Specifications

Detailed specifications for this chlorinated compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid
Type Chlorinated Compound
Category Chlorinated Compound · Heterocyclic Compound
Purity ≥95% (custom grades available)
Stereochemistry Defined configuration (chiral HPLC verified)
Complexity Moderate (2 functional groups, 2 rings)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Chlorinated Compounds

Handling Guidelines

Some chlorinated compounds are volatile or irritating. Use a fume hood and appropriate PPE. Acid chlorides react vigorously with water. Handle with standard laboratory precautions. Some heterocycles may be hygroscopic or irritating. Use adequate ventilation. Acids may be corrosive or irritating. Handle with chemical-resistant gloves and eye protection. Use a fume hood for volatile acids. Handle with standard precautions. Ensure proper labeling of stereochemical identity to prevent mix-ups.

Storage Conditions

Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base.

Why Buy 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid From ChemContract?

Quality Assured

Every batch of 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Questions

Frequently Asked

Common questions about 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid

What is 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid used for? +

1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid is a chloro-substituted intermediate widely used in nucleophilic displacement reactions used primarily in the pharmaceutical and agrochemical industries. Key applications include nucleophilic aromatic substitution (snar) for ether and amine formation and core scaffold in kinase inhibitor design for oncology therapeutics.

Where can I buy 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid in the USA? +

ChemContract Research is a trusted USA-based supplier of 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid? +

ChemContract Research supplies 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

What coupling reagents work best with 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid? +

For amide bond formation from the carboxylic acid in 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid, HATU/DIPEA is recommended for peptide coupling (high yield, low epimerization). EDC/HOBt is a cost-effective alternative for non-peptide amides. T3P (propylphosphonic acid anhydride) offers excellent atom economy with easy workup. For ester formation, DCC/DMAP (Steglich conditions) or Mitsunobu conditions are standard.

What coupling reactions can I run with 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid? +

As a chlorinated compound, 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.

How should I store 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid? +

Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid? +

The CAS Registry Number for 1,2,3,4-Tetrahydro-6-methyl-4-(4-chlorophenyl)-2-oxo-5-pyrimidinecarboxylic acid is 891190-52-6. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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