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1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide

CAS 37595-74-7 · Sulfur-Containing Compound · 4 functional traits · cGMP compliant · Ships from USA in 2-3 days

Sulfur-Containing Compound

1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide

Sulfonyl PharmaceuticalMedicinal ChemistryAgrochemicalPolymerDiagnostic ImagingMaterials Science
CAS Number 37595-74-7
Category Sulfur-Containing Compound · Fluorinated Compound
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide

1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide (CAS Number: 37595-74-7) is a sulfur-functionalized compound with diverse reactivity featuring a Benzene ring with defined stereochemistry. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.

Sulfonamides are one of the oldest and most successful pharmacophores in medicinal chemistry — present in antibiotics, diuretics, COX-2 inhibitors, and HIV protease inhibitors. The carbon–fluorine bond is the strongest single bond to carbon (485 kJ/mol). This exceptional stability underpins the "fluorine scan" strategy used in medicinal chemistry to optimize drug candidates. The amide bond is the single most common functional group in pharmaceutical compounds — its partial double-bond character provides both rigidity and hydrogen-bonding capability essential for target engagement.

Primary applications include sulfonamide pharmacophore installation for antibiotic and diuretic development and metabolic blocking strategy — fluorine substitution to improve drug half-life. This compound serves researchers and manufacturers across the pharmaceutical, medicinal chemistry, agrochemical sectors. Whether you require 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Benzene
Functional Groups: Amide (–CONH–)Fluorine (C–F)Sulfonamide (–SO₂NH–)
Stereochemistry: Defined Configuration

Sulfur-Containing Compound Applications & Target Industries

How 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide is used across pharmaceutical and medicinal chemistry sectors

01

Sulfonamide pharmacophore installation for antibiotic and diuretic development

02

Metabolic blocking strategy — fluorine substitution to improve drug half-life

03

Peptide bond mimetic for peptidomimetic drug design

04

Enantiopure building block for single-enantiomer drug development

05

Tosyl and mesyl protecting groups for hydroxyl and amine functionalities

06

PET radiotracer precursor ([¹⁸F]-labeling) for diagnostic imaging

Target Industries: PharmaceuticalMedicinal ChemistryAgrochemicalPolymerDiagnostic ImagingMaterials Science

1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide Specifications

Detailed specifications for this sulfur-containing compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide
Type Sulfur-Containing Compound
Category Sulfur-Containing Compound · Fluorinated Compound
Purity ≥95% (custom grades available)
Stereochemistry Defined configuration (chiral HPLC verified)
Complexity Moderate (3 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Sulfur-Containing Compounds

Handling Guidelines

Some sulfur compounds have strong odors. Handle in a well-ventilated fume hood. Consult the SDS for compound-specific hazards. Handle with care in a well-ventilated fume hood. Some fluorinated compounds may release HF upon decomposition. Use chemical-resistant gloves. Handle with standard laboratory precautions. Consult the SDS for compound-specific hazards. Handle with standard precautions. Ensure proper labeling of stereochemical identity to prevent mix-ups.

Storage Conditions

Store in a cool, dry place in a tightly sealed container. Protect from moisture and light as specified. Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature or as specified. Keep tightly sealed and protect from moisture. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base.

Why Buy 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide From ChemContract?

Quality Assured

Every batch of 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide

What is 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide used for? +

1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide is a sulfur-functionalized compound with diverse reactivity used primarily in the pharmaceutical and medicinal chemistry industries. Key applications include sulfonamide pharmacophore installation for antibiotic and diuretic development and metabolic blocking strategy — fluorine substitution to improve drug half-life.

Where can I buy 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide in the USA? +

ChemContract Research is a trusted USA-based supplier of 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide? +

ChemContract Research supplies 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

Why is fluorine important in 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide? +

The fluorine atom(s) in 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide valuable in pharmaceutical development.

What is the stereochemical purity of 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide? +

ChemContract Research supplies 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide with verified enantiomeric or diastereomeric purity as documented in our Certificate of Analysis (CoA). Chiral HPLC analysis is standard for stereodefined compounds. We can provide material with ≥98% ee/de for demanding applications. Contact us for specific optical purity requirements.

How should I store 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide? +

Store in a cool, dry place in a tightly sealed container. Protect from moisture and light as specified. Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature or as specified. Keep tightly sealed and protect from moisture. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide? +

The CAS Registry Number for 1,1,1-trifluoro-N-phenyl-N-trifluoromethanesulfonylmethanesulfonamide is 37595-74-7. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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