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1-Benzyl-4-formylpiperidine

CAS 22065-85-6 · Aldehyde · 3 functional traits · cGMP compliant · Ships from USA in 2-3 days

Aldehyde

1-Benzyl-4-formylpiperidine

Piperidines PharmaceuticalFragrance & FlavorFine ChemicalResearchCNS TherapeuticsMedicinal Chemistry
CAS Number 22065-85-6
Category Aldehyde · Piperidine
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About 1-Benzyl-4-formylpiperidine

1-Benzyl-4-formylpiperidine (CAS Number: 22065-85-6) is an aldehyde with a highly electrophilic carbonyl group featuring a Piperidine ring with defined stereochemistry. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.

The aldehyde carbonyl is one of the most reactive electrophilic centers in organic chemistry, enabling diverse transformations from imine formation to asymmetric allylation. The piperidine ring is the most common nitrogen heterocycle in FDA-approved drugs, appearing in over 70 marketed pharmaceuticals across CNS, cardiovascular, and oncology indications. Chirality matters profoundly in drug action — enantiomers can differ by orders of magnitude in potency, and FDA guidelines increasingly require single-enantiomer development.

Primary applications include reductive amination for c–n bond formation in api synthesis and cns drug scaffold (present in donepezil, methylphenidate, fentanyl class). This compound serves researchers and manufacturers across the pharmaceutical, fragrance & flavor, fine chemical sectors. Whether you require 1-Benzyl-4-formylpiperidine for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Piperidine
Functional Groups: Aldehyde (–CHO)
Stereochemistry: Defined Configuration

Aldehyde Applications & Target Industries

How 1-Benzyl-4-formylpiperidine is used across pharmaceutical and fragrance & flavor sectors

01

Reductive amination for C–N bond formation in API synthesis

02

CNS drug scaffold (present in donepezil, methylphenidate, fentanyl class)

03

Enantiopure building block for single-enantiomer drug development

04

Wittig and Horner–Wadsworth–Emmons olefination substrates

05

Conformationally-restricted amine for receptor binding optimization

06

Chiral resolution standard or chiral HPLC reference compound

Target Industries: PharmaceuticalFragrance & FlavorFine ChemicalResearchCNS TherapeuticsMedicinal Chemistry

1-Benzyl-4-formylpiperidine Specifications

Detailed specifications for this aldehyde, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 1-Benzyl-4-formylpiperidine
Type Aldehyde
Category Aldehyde · Piperidine
Purity ≥95% (custom grades available)
Stereochemistry Defined configuration (chiral HPLC verified)
Complexity Moderate (1 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Aldehydes

Handling Guidelines

Aldehydes can be irritating to skin, eyes, and respiratory tract. Handle in a well-ventilated fume hood. Many are volatile and flammable. Handle with standard precautions. Piperidine and some derivatives have strong amine odors. Use a fume hood. Handle with standard precautions. Ensure proper labeling of stereochemical identity to prevent mix-ups.

Storage Conditions

Store at recommended temperature under inert atmosphere. Protect from air to prevent oxidation to the corresponding carboxylic acid. Store at room temperature in a well-sealed container. Some N-unsubstituted piperidines are volatile. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base.

Why Buy 1-Benzyl-4-formylpiperidine From ChemContract?

Quality Assured

Every batch of 1-Benzyl-4-formylpiperidine is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 1-Benzyl-4-formylpiperidine? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about 1-Benzyl-4-formylpiperidine

What is 1-Benzyl-4-formylpiperidine used for? +

1-Benzyl-4-formylpiperidine is an aldehyde with a highly electrophilic carbonyl group used primarily in the pharmaceutical and fragrance & flavor industries. Key applications include reductive amination for c–n bond formation in api synthesis and cns drug scaffold (present in donepezil, methylphenidate, fentanyl class).

Where can I buy 1-Benzyl-4-formylpiperidine in the USA? +

ChemContract Research is a trusted USA-based supplier of 1-Benzyl-4-formylpiperidine. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 1-Benzyl-4-formylpiperidine? +

ChemContract Research supplies 1-Benzyl-4-formylpiperidine in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 1-Benzyl-4-formylpiperidine in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 1-Benzyl-4-formylpiperidine from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

What drug discovery applications use 1-Benzyl-4-formylpiperidine? +

The Piperidine ring system(s) in 1-Benzyl-4-formylpiperidine is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.

What is the stereochemical purity of 1-Benzyl-4-formylpiperidine? +

ChemContract Research supplies 1-Benzyl-4-formylpiperidine with verified enantiomeric or diastereomeric purity as documented in our Certificate of Analysis (CoA). Chiral HPLC analysis is standard for stereodefined compounds. We can provide material with ≥98% ee/de for demanding applications. Contact us for specific optical purity requirements.

How should I store 1-Benzyl-4-formylpiperidine? +

Store at recommended temperature under inert atmosphere. Protect from air to prevent oxidation to the corresponding carboxylic acid. Store at room temperature in a well-sealed container. Some N-unsubstituted piperidines are volatile. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 1-Benzyl-4-formylpiperidine? +

The CAS Registry Number for 1-Benzyl-4-formylpiperidine is 22065-85-6. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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