Frequently Asked
Common questions about Indole-2-carboxylic acid, 4-methyl-
What is Indole-2-carboxylic acid, 4-methyl- used for?
Indole-2-carboxylic acid, 4-methyl- is a heterocycle-containing compound — the dominant scaffold class in approved pharmaceuticals used primarily in the pharmaceutical and medicinal chemistry industries. Key applications include core scaffold in kinase inhibitor design for oncology therapeutics and amide bond formation via edc/hobt or hatu coupling in peptide synthesis.
Where can I buy Indole-2-carboxylic acid, 4-methyl- in the USA?
ChemContract Research is a trusted USA-based supplier of Indole-2-carboxylic acid, 4-methyl-. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for Indole-2-carboxylic acid, 4-methyl-?
ChemContract Research supplies Indole-2-carboxylic acid, 4-methyl- in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize Indole-2-carboxylic acid, 4-methyl- in custom quantities?
Yes. ChemContract Research offers custom synthesis services for Indole-2-carboxylic acid, 4-methyl- from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What coupling reagents work best with Indole-2-carboxylic acid, 4-methyl-?
For amide bond formation from the carboxylic acid in Indole-2-carboxylic acid, 4-methyl-, HATU/DIPEA is recommended for peptide coupling (high yield, low epimerization). EDC/HOBt is a cost-effective alternative for non-peptide amides. T3P (propylphosphonic acid anhydride) offers excellent atom economy with easy workup. For ester formation, DCC/DMAP (Steglich conditions) or Mitsunobu conditions are standard.
What drug discovery applications use Indole-2-carboxylic acid, 4-methyl-?
The Indole ring system(s) in Indole-2-carboxylic acid, 4-methyl- is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.
How should I store Indole-2-carboxylic acid, 4-methyl-?
Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of Indole-2-carboxylic acid, 4-methyl-?
The CAS Registry Number for Indole-2-carboxylic acid, 4-methyl- is 18474-57-2. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
