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2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester

CAS 1788894-41-6 · Boronic Acid / Boronate Ester · 5 functional traits · cGMP compliant · Ships from USA in 2-3 days

Boronic Acid / Boronate Ester

2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester

Heterocycles PharmaceuticalMedicinal ChemistryDiagnosticsAgrochemicalCatalysisPolymer
CAS Number 1788894-41-6
Category Boronic Acid / Boronate Ester · Heterocyclic Compound
Origin USA
Compliance cGMP

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About 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester

2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester (CAS Number: 1788894-41-6) is a boronic acid derivative valued for its role in carbon–carbon bond-forming reactions featuring Thiophene, Dioxaborolane (Pinacol boronate) ring systems with defined stereochemistry. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.

The boron atom in this compound enables transmetalation with palladium catalysts, making it a cornerstone reagent for Suzuki coupling — one of the most widely used reactions in pharmaceutical process chemistry. Heterocyclic rings appear in approximately 85% of all biologically active compounds. The nitrogen, oxygen, or sulfur heteroatom modulates electron density, hydrogen bonding, and aqueous solubility. Carboxylic acids are among the most synthetically versatile functional groups — they can be converted to amides, esters, acid chlorides, anhydrides, alcohols, and aldehydes in a single step.

Primary applications include suzuki–miyaura cross-coupling for biaryl and heterobiaryl synthesis and core scaffold in kinase inhibitor design for oncology therapeutics. This compound serves researchers and manufacturers across the pharmaceutical, medicinal chemistry, diagnostics sectors. Whether you require 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: ThiopheneDioxaborolane (Pinacol boronate)
Functional Groups: Carboxylic acid (–COOH)Ester (–COOR)
Stereochemistry: Defined Configuration

Boronic Acid / Boronate Ester Applications & Target Industries

How 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester is used across pharmaceutical and medicinal chemistry sectors

01

Suzuki–Miyaura cross-coupling for biaryl and heterobiaryl synthesis

02

Core scaffold in kinase inhibitor design for oncology therapeutics

03

Amide bond formation via EDC/HOBt or HATU coupling in peptide synthesis

04

Prodrug development to mask carboxylic acids and improve membrane permeability

05

Enantiopure building block for single-enantiomer drug development

06

Proteasome inhibitor design in oncology drug development

Target Industries: PharmaceuticalMedicinal ChemistryDiagnosticsAgrochemicalCatalysisPolymer

2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester Specifications

Detailed specifications for this boronic acid / boronate ester, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester
Type Boronic Acid / Boronate Ester
Category Boronic Acid / Boronate Ester · Heterocyclic Compound
Purity ≥95% (custom grades available)
Stereochemistry Defined configuration (chiral HPLC verified)
Complexity Moderate (2 functional groups, 2 rings)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Boronic Acid / Boronate Esters

Handling Guidelines

Boronic acids are generally air-stable but some may be moisture-sensitive and undergo protodeboronation. Handle with gloves and safety glasses. Handle with standard laboratory precautions. Some heterocycles may be hygroscopic or irritating. Use adequate ventilation. Acids may be corrosive or irritating. Handle with chemical-resistant gloves and eye protection. Use a fume hood for volatile acids. Some esters are volatile and flammable. Handle in a well-ventilated area. Keep away from ignition sources. Handle with standard precautions. Ensure proper labeling of stereochemical identity to prevent mix-ups.

Storage Conditions

Store in a tightly sealed container at room temperature under dry conditions. Protect from prolonged moisture exposure. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base.

Why Buy 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester From ChemContract?

Cross-Coupling Expertise

Our chemists optimize Suzuki and Chan–Lam coupling conditions for boronic acid building blocks like 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester. Get application support alongside your order.

Quality Assured

Every batch of 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Questions

Frequently Asked

Common questions about 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester

What is 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester used for? +

2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester is a boronic acid derivative valued for its role in carbon–carbon bond-forming reactions used primarily in the pharmaceutical and medicinal chemistry industries. Key applications include suzuki–miyaura cross-coupling for biaryl and heterobiaryl synthesis and core scaffold in kinase inhibitor design for oncology therapeutics.

Where can I buy 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester in the USA? +

ChemContract Research is a trusted USA-based supplier of 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester? +

ChemContract Research supplies 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

What coupling reagents work best with 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester? +

For amide bond formation from the carboxylic acid in 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester, HATU/DIPEA is recommended for peptide coupling (high yield, low epimerization). EDC/HOBt is a cost-effective alternative for non-peptide amides. T3P (propylphosphonic acid anhydride) offers excellent atom economy with easy workup. For ester formation, DCC/DMAP (Steglich conditions) or Mitsunobu conditions are standard.

What drug discovery applications use 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester? +

The Thiophene and Dioxaborolane (Pinacol boronate) ring system(s) in 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.

How should I store 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester? +

Store in a tightly sealed container at room temperature under dry conditions. Protect from prolonged moisture exposure. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester? +

The CAS Registry Number for 2-?Thiopheneacetic acid, 5-?(4,?4,?5,?5-?tetramethyl-?1,?3,?2-?dioxaborolan-?2-?yl)?-?, methyl ester is 1788894-41-6. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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