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Custom Synthesis & Manufacturing

FDA-Registered Facility

Custom Chemical Synthesis & Contract Manufacturing

From milligrams to kilograms, we deliver precision organic synthesis solutions for pharmaceutical, agrochemical, and specialty chemical industries.

25+Years Experience
500+Projects Completed
PhDExpert Chemists

Comprehensive Custom Synthesis Solutions

Expert organic chemistry services tailored to your specific requirements, from route development to commercial-scale production.

01

Multi-Step Organic Synthesis

Complex molecule synthesis with expertise in diverse reaction types and challenging chemistry. Our PhD chemists develop efficient routes for your target compounds.

  • Route development & optimization
  • Heterocyclic synthesis expertise
  • Chiral chemistry & resolution
  • Protecting group strategies
  • 5-15+ step syntheses
02

Process Scale-Up

Seamless transition from laboratory to commercial production while maintaining quality and optimizing cost-efficiency.

  • Lab scale: mg to 100g
  • Pilot scale: 100g to 10kg
  • Commercial: 10kg and beyond
  • Process optimization
  • Safety assessments
03

Analytical & Quality Control

State-of-the-art analytical capabilities ensuring the highest purity and quality standards for every compound we produce.

  • NMR (1H, 13C, 2D experiments)
  • HPLC/UPLC analysis
  • GC-MS & LC-MS
  • Complete COA documentation
  • Regulatory support
04

Custom Route Development

Innovative synthetic strategies designed for efficiency, scalability, and cost-effectiveness from concept to execution.

  • Literature research
  • Feasibility studies
  • Alternative route evaluation
  • IP-conscious design
  • Cost optimization

Our Streamlined Process

A collaborative approach that ensures your project moves efficiently from initial consultation to final delivery.

1

Consultation

Discuss project requirements and evaluate feasibility with our expert team

2

Planning

Develop synthetic route with timeline and cost estimates

3

Development

Lab-scale synthesis to validate and optimize the route

4

Production

Full-scale synthesis with rigorous quality controls

5

Analysis

Comprehensive testing and complete documentation

6

Delivery

Secure packaging and ongoing technical support

Trusted Across Multiple Sectors

We provide specialized synthesis solutions to leading companies in pharmaceutical, agrochemical, and specialty chemical industries worldwide.

💊

Pharmaceutical & Biotech

Supporting drug discovery and development with high-quality intermediates and active pharmaceutical ingredients.

  • Drug intermediates synthesis
  • API manufacturing
  • Research compounds
  • Reference standards
  • Metabolite synthesis

🌾 Agrochemical

Active ingredients and intermediates for crop protection and agricultural applications.

⚡ Specialty Chemicals

Custom molecules for materials science, coatings, and advanced applications.

🔬 Research Institutions

Building blocks and specialized compounds for academic and industrial research.

Frequently Asked Questions

Find answers to the most common questions about our custom chemical synthesis and contract manufacturing services.

What is the typical timeline for custom synthesis projects?+

Project timelines vary based on complexity and scale. Simple 2-3 step syntheses can be completed in 4-6 weeks, while complex multi-step syntheses (10+ steps) may take 3-6 months. We provide detailed timelines during the feasibility study phase and maintain transparent communication throughout the project.

Typical timeframes:

  • Simple synthesis (1-3 steps): 4-6 weeks
  • Moderate complexity (4-7 steps): 8-12 weeks
  • Complex synthesis (8-15+ steps): 3-6 months
  • Scale-up projects: Add 2-4 weeks per scale transition
What is the minimum order quantity for custom synthesis?+

We're flexible with project sizes. Our minimum is typically 100mg for research compounds, but we can discuss smaller quantities for specialized projects. We scale seamlessly from milligrams to multi-kilogram production as your needs evolve.

Scale ranges we support:

  • Research scale: 100mg - 10g
  • Lab scale: 10g - 100g
  • Pilot scale: 100g - 10kg
  • Commercial scale: 10kg and beyond

Contact us to discuss your specific quantity requirements.

Do you offer process development services?+

Yes, process development is one of our core strengths. Our team excels at developing efficient synthetic routes, optimizing existing processes, and scaling reactions from lab to production scale. We use our expertise to improve yields, reduce costs, and enhance safety.

Our process development services include:

  • Literature research and feasibility studies
  • Alternative route evaluation and selection
  • Reaction optimization (yield, purity, cost)
  • Safety and hazard assessments
  • Impurity profiling and control strategies
  • Scale-up protocols and technology transfer
How do you ensure quality and purity?+

Our FDA-registered facility follows rigorous QC protocols. Every compound undergoes comprehensive analytical testing including NMR, HPLC, GC-MS, and other techniques as appropriate. We provide complete certificates of analysis with all deliverables and maintain detailed batch records.

Our analytical capabilities include:

  • NMR Spectroscopy: 1H, 13C, 2D experiments (COSY, HSQC, HMBC)
  • Chromatography: HPLC/UPLC, GC, preparative HPLC
  • Mass Spectrometry: GC-MS, LC-MS, high-resolution MS
  • Other techniques: IR, UV-Vis, melting point, optical rotation

All compounds are delivered with complete certificates of analysis (COA) including structure confirmation, purity assessment, and full characterization data.

Can you scale from lab to commercial quantities?+

Absolutely. We specialize in seamless scale-up from research quantities (mg) through pilot scale (100g-10kg) to commercial production (10kg+). Our process chemists optimize each step for scalability while maintaining the quality and purity standards established at lab scale.

Our scale-up approach:

  • Progressive scaling with validation at each stage
  • Process parameter optimization (temperature, concentration, etc.)
  • Equipment selection and safety considerations
  • Cost reduction strategies without compromising quality
  • Technology transfer support for your own facilities

We maintain the same team throughout your project to ensure consistency and institutional knowledge.

What industries do you serve with custom synthesis services?+

We provide custom synthesis services to pharmaceutical companies (drug intermediates, API synthesis), agrochemical companies (active ingredients), specialty chemical manufacturers, biotechnology firms (research compounds), and academic research institutions.

Primary industries and applications:

  • Pharmaceutical: Drug intermediates, APIs, metabolites, reference standards
  • Agrochemical: Active ingredients, intermediates for herbicides, pesticides, fungicides
  • Specialty Chemicals: Advanced materials, electronic chemicals, specialty polymers
  • Biotechnology: Building blocks, research tools, probe molecules
  • Academic Research: Novel compounds, methodology development
Are you FDA registered and GMP certified?+

Yes, ChemContract Research operates an FDA-registered facility with GMP certification. We maintain rigorous quality control procedures and provide complete documentation including certificates of analysis (COA) for all synthesized compounds.

Our certifications and compliance:

  • FDA-registered chemical manufacturing facility
  • GMP (Good Manufacturing Practice) certified laboratory
  • ISO 9001:2015 quality management systems (if applicable)
  • Comprehensive documentation and batch records
  • Regulatory support for IND/NDA submissions
  • Audit-ready facility and documentation
Where is ChemContract Research located?+

ChemContract Research is located in Huntington Beach, California at 9121 Atlanta Ave, Suite 800, CA 92646. Our facility is easily accessible from major Southern California locations and close to John Wayne Airport (SNA).

Contact information:

  • Phone: +1 (714) 732-8549
  • Email: [email protected]
  • Address: 9121 Atlanta Ave, Suite 800, Huntington Beach, CA 92646
  • Hours: Monday-Friday, 8:00 AM - 5:00 PM PST

We serve clients worldwide from our Southern California facility.

What types of chemistry do you specialize in?+

Our PhD chemists have extensive experience across a wide range of organic chemistry disciplines. We specialize in complex multi-step syntheses and challenging transformations.

Areas of expertise include:

  • Heterocyclic chemistry: Pyridines, indoles, quinolines, benzofurans, thiophenes, etc.
  • Chiral chemistry: Asymmetric synthesis, chiral resolution, chiral auxiliaries
  • Organometallic chemistry: Grignard, organolithium, palladium-catalyzed reactions
  • Protecting group chemistry: Complex protection/deprotection strategies
  • Natural product synthesis: Total synthesis and analog preparation
  • Medicinal chemistry: Drug-like molecules, SAR studies
How do you handle confidentiality and intellectual property?+

We take confidentiality and IP protection extremely seriously. All projects begin with a Confidential Disclosure Agreement (CDA) or Non-Disclosure Agreement (NDA). Your proprietary information, structures, and processes remain strictly confidential.

Our IP protection measures:

  • Standard CDAs/NDAs with all clients
  • Restricted access to project information on a need-to-know basis
  • Secure data storage and disposal protocols
  • No publication or disclosure of client projects
  • Clear ownership of IP developed during projects
  • Option for custom agreements tailored to your needs

Your intellectual property is safe with us.

What information do you need to provide a quote?+

To provide an accurate quote, we need some basic information about your synthesis project. The more details you can provide, the more precise our estimate will be.

Information needed for quotation:

  • Target molecule: Structure (SMILES, MOL file, or drawn structure)
  • Quantity required: Desired amount and timeline
  • Purity requirements: Minimum acceptable purity (typically ≥95%, ≥98%, etc.)
  • Starting materials: Any preferred starting points or constraints
  • Additional requirements: Analytical data needed, regulatory compliance, etc.

We typically provide detailed quotes within 48 hours of receiving complete information.

Do you offer rush or expedited synthesis services?+

Yes, we understand that some projects have urgent timelines. We offer expedited synthesis services for time-sensitive projects, subject to chemistry complexity and current capacity.

Expedited service options:

  • Priority scheduling for urgent projects
  • Extended work hours including weekends when necessary
  • Real-time project updates and communication
  • Fast-track analytical testing

Contact us to discuss your timeline requirements and we'll work to accommodate your needs.

Can you work with hazardous or challenging chemistry?+

Yes, our facility is equipped to handle a wide range of challenging chemistries, including hazardous reactions, cryogenic conditions, high pressure, and air/moisture-sensitive reagents.

Capabilities include:

  • Cryogenic reactions: Down to -78°C and below
  • High temperature: Up to 200°C in specialized equipment
  • High pressure: Hydrogenations and other pressure reactions
  • Inert atmosphere: Schlenk techniques, glove box work
  • Hazardous reagents: Proper handling of reactive/toxic materials
  • Controlled substances: DEA-licensed for Schedule I-V compounds

All hazardous work is conducted with comprehensive safety protocols and risk assessments.

What payment terms do you offer?+

We offer flexible payment terms for established clients and can work with purchase orders, milestone payments, or custom arrangements based on project scope.

Typical payment structures:

  • New clients: 50% deposit, 50% upon delivery
  • Established clients: Net 30 payment terms with approved credit
  • Large projects: Milestone-based payments aligned with project phases
  • Accepted methods: Wire transfer, ACH, credit card, purchase orders

Contact our sales team to discuss payment terms that work for your organization.

Do you offer international shipping?+

Yes, we ship compounds worldwide. Our team handles all necessary export documentation, customs paperwork, and compliance requirements for international shipments.

International shipping services:

  • Worldwide shipping with reliable carriers (FedEx, DHL, UPS)
  • Proper packaging for chemical transport (UN-certified containers)
  • Complete export documentation and customs support
  • Material Safety Data Sheets (MSDS/SDS) in multiple languages
  • Compliance with international chemical regulations
  • Temperature-controlled shipping when required

We ensure your compounds arrive safely regardless of destination.

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