CAS 655254-61-8 · Sulfur-Containing Compound · 3 functional traits · cGMP compliant · Ships from USA in 2-3 days
?-Tosyl-(4-bromobenzyl)isocyanide (CAS Number: 655254-61-8) is a sulfur-functionalized compound with diverse reactivity with defined stereochemistry. ChemContract Research supplies this simple-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.
Sulfonamides are one of the oldest and most successful pharmacophores in medicinal chemistry — present in antibiotics, diuretics, COX-2 inhibitors, and HIV protease inhibitors. Aryl and alkyl bromides occupy a "Goldilocks zone" in cross-coupling — more reactive than chlorides yet more stable than iodides — making them the most commonly used coupling partners in process chemistry. Chirality matters profoundly in drug action — enantiomers can differ by orders of magnitude in potency, and FDA guidelines increasingly require single-enantiomer development.
Primary applications include sulfonamide pharmacophore installation for antibiotic and diuretic development and grignard reagent preparation via magnesium insertion into c–br bond. This compound serves researchers and manufacturers across the pharmaceutical, medicinal chemistry, agrochemical sectors. Whether you require ?-Tosyl-(4-bromobenzyl)isocyanide for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.
How ?-Tosyl-(4-bromobenzyl)isocyanide is used across pharmaceutical and medicinal chemistry sectors
Sulfonamide pharmacophore installation for antibiotic and diuretic development
Grignard reagent preparation via magnesium insertion into C–Br bond
Enantiopure building block for single-enantiomer drug development
Tosyl and mesyl protecting groups for hydroxyl and amine functionalities
Palladium-catalyzed Suzuki, Heck, and Negishi cross-coupling
Chiral resolution standard or chiral HPLC reference compound
Detailed specifications for this sulfur-containing compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:
Some sulfur compounds have strong odors. Handle in a well-ventilated fume hood. Consult the SDS for compound-specific hazards. Some brominated compounds may be lachrymatory or skin irritants. Handle in a fume hood with appropriate PPE. Handle with standard precautions. Ensure proper labeling of stereochemical identity to prevent mix-ups.
Store in a cool, dry place in a tightly sealed container. Protect from moisture and light as specified. Store at room temperature in a tightly sealed, light-resistant container. Some bromo compounds require refrigeration. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base.
Every batch of ?-Tosyl-(4-bromobenzyl)isocyanide is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.
Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.
Need a specific grade, quantity, or derivative of ?-Tosyl-(4-bromobenzyl)isocyanide? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.
Common questions about ?-Tosyl-(4-bromobenzyl)isocyanide
?-Tosyl-(4-bromobenzyl)isocyanide is a sulfur-functionalized compound with diverse reactivity used primarily in the pharmaceutical and medicinal chemistry industries. Key applications include sulfonamide pharmacophore installation for antibiotic and diuretic development and grignard reagent preparation via magnesium insertion into c–br bond.
ChemContract Research is a trusted USA-based supplier of ?-Tosyl-(4-bromobenzyl)isocyanide. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
ChemContract Research supplies ?-Tosyl-(4-bromobenzyl)isocyanide in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Yes. ChemContract Research offers custom synthesis services for ?-Tosyl-(4-bromobenzyl)isocyanide from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
As a brominated compound, ?-Tosyl-(4-bromobenzyl)isocyanide is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.
ChemContract Research supplies ?-Tosyl-(4-bromobenzyl)isocyanide with verified enantiomeric or diastereomeric purity as documented in our Certificate of Analysis (CoA). Chiral HPLC analysis is standard for stereodefined compounds. We can provide material with ≥98% ee/de for demanding applications. Contact us for specific optical purity requirements.
Store in a cool, dry place in a tightly sealed container. Protect from moisture and light as specified. Store at room temperature in a tightly sealed, light-resistant container. Some bromo compounds require refrigeration. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
The CAS Registry Number for ?-Tosyl-(4-bromobenzyl)isocyanide is 655254-61-8. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
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